Stekovic, S; Hofer, SJ; Tripolt, N; Aon, MA; Royer, P; Pein, L; Stadler, JT; Pendl, T; Prietl, B; Url, J; Schroeder, S; Tadic, J; Eisenberg, T; Magnes, C; Stumpe, M; Zueger, E; Bordag, N; Riedl, R; Schmidt, A; Kolesnik, E; Verheyen, N; Springer, A; Madl, T; Sinner, F; de Cabo, R; Kroemer, G; Obermayer-Pietsch, B; Denjel, J; Sourij, H; Pieber, TR; Madeo, F
Aug 27, 2019
Cell Metabolism, vol. 30, no. 3, Sept. 2019, pp. 462–76, https://doi.org/10.1016/j.cmet.2019.07.016.
Caloric restriction and intermittent fasting are known to prolong life- and healthspan in model organisms, while their effects on humans are less well studied. In a randomized controlled trial study (ClinicalTrials.gov identifier: NCT02673515), we show that 4 weeks of strict alternate day fasting (ADF) improved markers of general health in healthy, middle-aged humans while causing a 37% calorie reduction on average. No adverse effects occurred even after >6 months. ADF improved cardiovascular markers, reduced fat mass (particularly the trunk fat), improving the fat-to-lean ratio, and increased β-hydroxybutyrate, even on non-fasting days. On fasting days, the pro-aging amino-acid methionine, among others, was periodically depleted, while polyunsaturated fatty acids were elevated. We found reduced levels sICAM-1 (an age-associated inflammatory marker), low-density lipoprotein, and the metabolic regulator triiodothyronine after long-term ADF. These results shed light on the physiological impact of ADF and supports its safety. ADF could eventually become a clinically relevant intervention.
Full Text: https://pubmed.ncbi.nlm.nih.gov/31471173/
Aging, Alternate-Day Fasting
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